We employ in-cell NMR spectroscopy to study the structural and functional properties of proteins inside live cells.
Using this method, our laboratory explores physiological and pathophysiological protein states in different cellular environments and under different cellular conditions.
The background image depicts the 'inside' of a typical eukaryotic cell. It illustrates the highly crowded nature and overwhelming complexity of the intracellular environment.
Low-resolution light-microscopy image of a Xenopus laevis oocyte thin section, H&E stained, false color coded. The spherical structure in the middle is the cell nucleus or germinal vesicle.