The CGU is a compact and cost-effective fluorescence microscope that integrates the rapid imaging capabilities of widefield microscopy with the 3D-sectioning advantages of confocal microscopy. Its design utilizes a line-scan confocal module coupled with a sensitive camera detector, enabling full field-of-view acquisition rates in the kilohertz range, diffraction-limited resolution, and single-molecule sensitivity. This configuration provides the speed and ease of use characteristic of widefield imaging, combined with the optical sectioning of one-photon confocal imaging. The straightforward optical layout allows for the use of fast scanning mirrors, making it suitable for various applications, from research to diagnostics and screening.
ResearchGate
In comparison, established commercial systems like the Yokogawa CSU series offer field-scanning confocal systems known for their specimen-friendly characteristics and enhanced signal-to-noise ratios. These systems are integrated with Nikon's microscope platforms, providing flexibility and high-speed imaging capabilities.
Nikon Healthcare
For those seeking a balance between performance and affordability, the CGU presents an innovative solution, leveraging a simplified optical design to achieve high-speed, high-resolution imaging without the complexity and cost of traditional confocal systems.
